Manchester United should be firmly in the driver's seat for this match. An upset victory and three points would instantly change their fortunes, however.
United have won five on the bounce and face a Crystal Palace side who are yet to score this season.
Defeats in the first four cost Frank de Boer his job as manager having only been appointed over the summer, but things haven't gone much better for his successor, Roy Hodgson.
It is essentially a game of top versus bottom as Manchester United host Crystal Palace at Old Trafford.
The Red Devils have never lost a Premier League game to Palace.
GETTY Swedish striker Zlatan Ibrahimovic missed the end of last season due to a serious knee injury
Man United starting XI: De Gea, Valencia, Bailly, Jones, Darmian, Matic, Herrera, Rashford, Mhkitaryan, Martial, Lukaku.
For the Eagles, meanwhile, Bakary Sako has come in to replace the injured Christian Benteke, who has been ruled out for six weeks with a knee ligament damage. Timothy Fosu-Mensah is ineligible as his temporary side face his parent club.
Ruben Loftus-Cheek has a thigh strain, while James Tomkins is sick and Conor Wickham and Wilfried Zaha remain long-term absentees.
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Sako was used in the role in the League Cup win over Huddersfield, and Hodgson said: "We were satisfied with his performance that day, and the fact he scored". A team out of form and without a recognised centre-forward, it is hard to imagine a situation where the Eagles could provide a shock this weekend.
The two teams could go in this fixture in any more contrasting form if they tried. The former England manager will be praying for a miracle on Saturday afternoon, but is likely to see his side battered by a rampant and in form United team.