If this was De Boer's farewell, it seemed a strangely fitting way to go.
So, for the trip to Burnley, De Boer abandoned his three-at-the-back philosophy in favour of a 4-3-3 set-up more familiar to his Palace players.
Burnley's first appearance at Wembley ended with a degree of glory as they held last year's second-placed team to a draw. De Boer knows his position could be on the line.
A Lee Chung-yong error gifted Chris Wood the only goal in the third minute of the match, De Boer acknowledging the early blow hurt his side. Burnley's record signing provided an assured finish to vindicate Dyche, who promoted the £15m forward, the scorer of a late leveller against Tottenham last time out, to the starting 11. It may prove an accurate prediction, though the manager sounded unworried.
"I am just focusing on what I can control and so are my staff and my players", he said.
The Palace manager will be pleased that he is able to recall some of his other key men after they have returned to training following their own injury problems. Palace were the better side today, we didn't get into our stride at all. Here, we take a look at how it played out...
"But if you look all over at how we showed spirit, I think we were quite dynamic".
De Boer's frustration with the outcome of the game was clear in his post-match interview with Sky Sports.
Speaking to talkSPORT after the game, De Boer said: "I'm very disappointed". "Normally we are scheduled to come together one day a week to see what's happening and how we can improve". We controlled the game, we played on the ground, and we played through the air.
Palace are being kept off the foot of the table at present by West Ham, on goal difference, but that could change on Monday night - when the Hammers face Huddersfield.
The 20-year-old Sanches battled hard but was sloppy in possession, and had already been substituted by the time Jamaal Lascelles headed home Newcastle's winning goal from a corner in the 76th minute. "But that's football", De Boer said. Its best chance fell in the 89th minute to Scott Dann, who glanced a header wide from inside the six-yard box. "They had two fantastic chances, particularly Dann's". For Palace, Christian Benteke is available at 21/10 odds.
Manchester United and Manchester City lead the Premier League standings after Sunday's Week 4 fixtures, which didn't see any of the top title contenders in action.