Later in the night, Dear Evan Hansen was named best musical.
The acting mogul was thrilled to pick up her award for Best Performance by an Actress in a Leading Role in a Musical for Hello, Dolly! and celebrated with an extremely long speech.
Its star Rachel Bay Jones took the Tony for best featured actress in a musical.
The play has won rave reviews and a Hollywood movie adaptation is also in the works, planned by Marc Platt, producer of "La La Land", which won six Oscars at this year's Academy Awards.
And he thanked his "theatrical home", California's La Jolla Playhouse, where "Come From Away" was staged several years ago on its lengthy journey to Broadway. Unlike twelve months ago when "Hamilton" nearly swept the board, this year's Tonys were more even-handed. Midler took lead actress in a musical, her first-ever Tony win.
Don't mess with Bette - especially when she's just won an award..
J.T. Rogers' "Oslo", an ambitious account inspired by true events surrounding the Oslo Peace Accords between Israel and the Palestinian Liberation Organization, won best play.
The 71st annual Tony Awards will air live June 11 on CBS from New York's Radio City Music Hall.
But Midler wasn't going to let anyone come in her way.
Bette Midler, a victor for Hello, Dolly!
"Shut that crap off!" she lambasted the orchestra, while the audience cheered at her entertaining speech. Platt's performance from Evan Hansen was terrific, but the showstopper of the night belonged to the high-energy cast of Nastasha, Pierre, and the Great Comet of 1812. Performing the song, "I'd Give My Life For You", Noblezada was joined on stage by Alistair Brammer who plays the role of her son, Chris. Also recognized was the late August Wilson, whose "Jitney" was called the Best Revival of a Play.
On her 21st nomination, costume designer Jane Greenwood ("The Little Foxes") finally won her first competitive Tony. "I'm so grateful for the outpouring of love and affection that have greeted me and this production", she continued.
Host Kevin Spacey took an unorthodox approach to the job, trotting out impersonations - Bill Clinton, Johnny Carson and his own "House of Cards" Frank Underwood character - in lieu of a more conventional hosting technique.
"The View" co-host Whoopi Goldberg joined Spacey onstage to offer him advice about helming the show, and the duo engaged in tongue-in-cheek banter with a nod to Newfoundland. "And then to be representing my show and performing tonight - I just had the best time".