Ossoff aims to win an outright majority in Tuesday's vote, a "jungle primary" with all 18 candidates from both parties on the same ballot. Ms Handel did not mention Mr Trump during a 10-minute speech on Tuesday night, according to local media.
Republican Senator Lindsey Graham of SC said the race showed how the South was changing. Ossoff thus far hasn't focused on Handel (a former Georgia secretary of state), but Democratic strategists are well aware that she was once a senior official of a charity group that tried to slash funding grants for Planned Parenthood.
Nor was the Kansas district where, one week ago, a Republican candidate won a special congressional election by only seven points, in a ruby-red enclave that routinely elects House Republicans by 30 points.
Handel, who said Trump called to congratulate her on Wednesday morning, dismissed Ossoff as a well-funded novice who would flounder as Republicans consolidated support behind a single candidate. For example, Handel - Ossoff's GOP opponent in the runoff election - only raised $463,744 and spent $279,767 as of March 29.
However, what is concerning is that why do Congressional Republicans perceive Ossoff as a threat and why did Trump want him to lose so badly?
With 18 candidates in the race, Ossoff benefitted from united Democratic support, and a reported $8.3 million fundraising haul.
Pete Korman, 6th District voter, said national enthusiasm for Ossoff has been frustrating to watch, but he thinks Handel will win voters in the 6th. "This is a case of Democratic Party supporters taking a shot at Donald Trump; they can't because that election is over, so they take a shot at the party instead", the political scientist told The Straits Times over the phone.
On the Republican side, the White House press secretary called the election results "a big loss" for Democrats, saying the outcome "pretty much tracks" the results in the 2016 presidential election.
"Donald Trump coming to town could be the biggest thing to happen to congressional elections in years", said Todd Rehm, a Republican strategist and founder of the blog GeorgiaPundit.com, told VOA. There were four other Democrats in the race as well, although combined those candidates accounted for less than 1 percent of the vote.
The fact he was even competitive is mind-blowing to Washington Democrats.
With 185 of 210 precincts reporting, he held 48.3 percent of the vote - just shy of the 50 percent he needed to become the first Democrat to represent Atlanta's affluent northern suburbs since the 1970s. "Glad to be of help!"
Republicans have made their own attempts at nationalizing the campaign.