On a night honoring the late, great Jackie Robinson, the Atlanta Braves went for win number two at home and their third straight on the young season.
Inciarte caught the first out of the game (on the first pitch of the game), then got the first hit, scored the first run and, to put an exclamation point on things, hit the stadium's first home run in the sixth inning to give the Braves a 5-2 lead.
Colon, who has a 233-163 career record over 20 seasons, beat San Diego past year, allowing three runs over 6 2/3 innings, and is 3-3 with a 4.12 ERA in seven career starts against the Padres.
Renfroe deposited a 1-0 knuckler over the fence in left-center field for his third home run and Hedges hit his first of the season to left field on a 1-2 knuckleball. Following the fanfare of the opening ceremonies, which featured Major League Baseball commissioner Rob Manfred, Hall of Famers Hank Aaron, Chipper Jones and Bobby Cox and singer-songwriter Phillip Phillips, among others, center fielder Ender Inciarte snagged a first-pitch fly ball and recorded the first out in SunTrust history.
Inciarte's home run was his fourth in the last three games, more than he hit in 131 games last season.
One half-inning later, it was the Braves offense's turn to make some history.
Braves: Flowers left the game with a right hamstring strain and is day to day, according to Snitker.
Sean Manaea and Ryan Dull combined to pitch six hitless innings for Oakland, which led 5-0 before allowing two runs on two errors in the sixth to start Houston's rally.
Toles hit his third home run of the season, a two-run shot in the eighth that capped the scoring for the Dodgers.
Orioles extend Jays' woes: The Baltimore Orioles hit four homers, including three off starter Aaron Sanchez, earning their fourth win over the Blue Jays in as many meetings with a 6-4 victory at Toronto. He gave up both San Diego runs, working around four walks and two hit batters. He's hit safely in nine straight games and, since going 0-for-4 on opening day, is 11-for-33 with six RBI.
Chapman allowed a two-out walk to Randal Grichuk and a double to pinch-hitter Jose Martinez before Dexter Fowler - the closer's teammate on the World Series champion Cubs a year ago - grounded out to second to end it. Chapman got his third save on the season.
What he might not have figured on, however, was how many entries he would have on the all-time firsts list at SunTrust Park. Inciarte and Freddie Freeman, who reached on an intentional walk, scored on Phillips' two-out single up that middle that knocked Cahill out of the game. "I've got good hitters behind me and if I can get on base we are going to score a lot of runs".
Getting the nod for the Padres, will be former Brave, Trevor Cahill, also looking for his first win on the season.
Braves: RHP R.A. Dickey (0-1) will have the distinction of pitching in three different Braves stadiums.
Banks has been an usher for the Braves dating back to their first year at Atlanta-Fulton County Stadium in 1966.
Clayton Kershaw allowed a run and four hits with eight strikeouts and one walk in 8 1/3 innings to beat former teammate and Diamondbacks pitcher Zack Greinke.