Three Democratic senators - Joe Manchin of West Virginia, Joe Donnelly of IN and Heidi Heitkamp of North Dakota - joined their Republican colleagues to vote "yes" on Gorsuch's nomination.
Neil Gorsuch, the 49-year-old federal judge nominated by President Donald Trump as supreme court justice, was confirmed to the life-long position on Friday, restoring a conservative majority to the nine-member United States supreme court.
By "going nuclear" - a tactic President Trump suggested Republicans use, if necessary, soon after nominating Gorsuch - they broke the Democratic filibuster, virtually guaranteeing he will be confirmed in a 7 April vote requiring only a simple majority of 51.
In part Democrats opposed the nomination because Senate Republicans blocked former president Barack Obama's nominee Merrick Garland previous year.
"I applaud the U.S. Senate, and specifically Arkansas Senators John Boozman and Tom Cotton, for confirming Judge Neil Gorsuch to the U.S. Supreme Court".
Mr Gorsuch will officially be a member of the court once he takes the two oaths.
Judge Gorsuch may be qualified to sit on the high court, but he is on the verge of elevation only because of the rank political maneuvering of McConnell and his Republican colleagues in the Senate. As a outcome of the outrageous political maneuvering of Senate Republicans, the legitimacy of the Supreme Court itself is at risk.
Vice President Mike Pence presided over the vote, but was not needed to break a tie.
Republicans said Democrats had no one to blame but themselves, launching a filibuster they knew Republicans were determined to overcome.
"Congratulations to Colorado's Neil Gorsuch on being confirmed to the U.S. Supreme Court!" Still hurt over Judge Merrick Garland's snub past year, liberals and progressives have warned that Gorsuch's legacy will forever be tainted because of the GOP's unprecedented obstruction.
The chamber's majority leader tore up the rulebook after Democrats mounted the first filibuster of a Supreme Court nominee in half a century.
There are nine judges who sit on the Supreme Court, and they hold the position for life.