Warplanes launched Friday from the same Syrian air base that the US bombarded - blasting the village of Khan Shaykhun, which is still reeling from a chemical attack that killed at least 80 on Tuesday, according to the London-based Syrian Observatory for Human Rights.
An earlier death toll from the strike on the rebel stronghold of Urum al-Joz reported 15 people were killed, but three more died after sustaining serious injuries.
The U.S. government said the attack on the air base came in retaliation for the strikes by the Syrian air force on the town of Khan Sheikhoun on Tuesday.
Officially announcing the strike, US President Donald Trump claimed that the targeted airfield had launched the chemical attack on the rebel-held area in Idlib.
The spokesman further emphasized that the U.S. missile attack on the Syrian government will only strengthen the terrorists, who are on the verge of collapse and complicate the satiation in the Arab country and the region.
The U.S. strikes marked the first time during Syria's civil war that the U.S. directly. The Homs governor said on Friday the base was being used to provide air support for operations against Islamic State east of Palmyra.
"We hope for the continuation of the strikes in order to prevent the regime from using its planes to launch any new air raids or going back to using internationally banned weapons", said Ahmad Ramadan, head of the media office of the Syrian National Coalition political opposition group.
The US said the missiles targeted radars, aircraft, and air defence systems and destroyed around 20 Syrian planes, but said the runway was intact.