MI entered the tournament on a roll, having mounted a shocking, somewhat inspiring run to the Big Ten tournament title.
For the Cowboys, Jeffrey Carroll had a total of nine points and four rebounds in the first half.
Moreover, this is the 31st NCAA Tournament all-time trip for the Spartans.
The ninth-seeded Michigan State Spartans are moving on to the second round of the NCAA Tournament.
The Miami Hurricanes (21-11) are coming from a 78-53 loss to North Carolina in which Bruce Brown scored 21 points in 9-for-13 shooting from the field and 2-for-2 from the free throw line.
Forward Nick Ward scored 19 points to lead Michigan State.
MI shook off a frustrating first half, marred by foul trouble and adjustments to OSU's fast-paced style of play, to hold a 41-40 lead at the break.
Miami's young players have made an impact all season, but it was Michigan State's freshmen that fueled the Spartans comeback. The Cardinals have won all three meetings in the series, including the 2013 national championship game.
Miami will bring in the best recruiting class in school history on the heels of this year's class that previously was given that distinction.
Two of the nation's best offenses, coming off impressive second halves of the season, dueled in an exciting first-round matchup to begin Friday's tournament action, with No. 7 seed MI pulling off a 92-91 win over the No. 10 seed Cowboys in Indianapolis, thanks especially to absurdly prolific 3-point shooting. The 4:15 p.m. clash Sunday in the second round of the NCAA Tournament features bluebloods that annually participate in the Champions Classic.
SC won the program's first NCAA tournament game since 1973 on Friday. Kamari Murphy leads in rebounds with 7.5 while Newton leads in assists with 3.4 per game. But he had 19 points by halftime in this one, helping the Tar Heels (28-7) quickly eliminate any chance of an unprecedented upset. Defensively, Michigan State is yielding 68.4 points against the opposing teams.
Cincinnati (30-5) was knocked out the first round a year ago and No. 6 seeds were 0-3 before the Bearcats took the floor, with Maryland, Creighton and SMU all losing to No. 11 seeds. The Jayhawks allow 72.1 points per game, but some of that is a byproduct of their high-scoring ways as they can be suffocating at times.
Stewart had 22 points for the Trojans (26-9).
On Saturday, as the teams prepared to square off in the second round of the Midwest Region Sunday at the BOK Center, the topic came up again.
Despite trailing by as many as seven, MI was buoyed by 5-of-6 shooting from long range to start the decisive half.
The Mustangs lost despite Semi Ojeleye's 24 points and 10 rebounds.
The first round of March Madness is in the books while the second round is wrapping up.
MI is 5-0 ATS in their last 5 games following a win and 6-0 ATS in their last 6 games overall.
Walton became the first player to score at least 25 points, log at least 10 assists and five rebounds in an NCAA Tournament game since Dwyane Wade did so in 2003.